ACHIEVEMENT
Selected Publication
Uji M#, Kondo J#, Hara-Miyauchi C#, Akimoto S, Haruki R, Sasaki Y, Kimizuka N*, Ajioka I*, Yanai N* (*co-corresponding author)
In Vivo Optogenetics Based on Heavy Metal-Free Photon Upconversion Nanoparticles.
Adv Mater e2405509, 2024. doi: 10.1002/adma.202405509.
Yaguchi A#, Oshikawa M#, Watanabe G, Hiramatsu H, Uchida N, Hara C, Kaneko N, Sawamoto K, Muraoka T*, Ajioka I* (*co-corresponding author)
Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration
Nature Commun 12:6623, 2021
Technology Introduction (English)
Sasaki Y, Oshikawa M, Bharmoria P, Kouno H, Hayashi-Takagi A, Sato M, Ajioka I*, Yanai N*, Kimizuka N* (*co-corresponding author)
Near-infrared optogenetic genome engineering based on photon upconversion hydrogels
Angew Chem Int Ed 58:17827-17833, 2019
Oshikawa M, Okada K, Kaneko N, Sawamoto K, and Ajioka I* (*corresponding author)
Affinity-Immobilization of VEGF on laminin porous sponge enhances angiogenesis in the ischemic brain
Adv Healthc Mater 1700183, 2017.
Oshikawa M, Okada K, Tabata H, Nagata KI, and Ajioka I* (*corresponding author)
Dnmt1-dependent Chk1 pathway suppression is protective against neuron division
Development 144, 3303-3314, 2017
Aldiri I#, Ajioka I#, Xu B, Zhang J, Chen X, Benavente C, Finkelstein D, Johnson D, Akiyama J, Pennacchio LA, and Dyer MA (#co-first author)
Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma
Development 142, 4092-4106, 2015.
Oshikawa M, Okada K, Nakajima K, Ajioka I* (*corresponding author)
Cortical excitatory neurons become protected from cell division during neurogenesis in an Rb family-dependent manner
Development 140:2310-2320, 2013.
Ajioka I*, Ichinose S, Nakajima K, Mizusawa H. (*corresponding author)
Basement membrane-like matrix sponge for the three-dimensional proliferation culture of differentiated retinal horizontal interneurons.
Biomaterials 32:5765-5772, 2011.
Ajioka I, Martins R, Bayazitov IT, Donovan S, Johnson D, Frase S, Cicero S, Boyd K, Zakharenko SS, Dyer MA.
Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice
Cell 131:378-390, 2007.
Full Publication (click here)
2026
Daiki Miura, Koichiro Ishibashi, Chikako Hara-Miyauchi, Saori Akimoto, Itsuki Ajioka*, Go Watanabe* (*co-corresponding author)
"A Supramolecular Transition Underlies the Pathogenic Threshold in Polyglutamine Disease"
ChemRxiv. 19 June 2026. DOI: https://doi.org/10.26434/chemrxiv.15004960/v1
Atsuya Yaguchi, Chikako Hara-Miyauchi, Haruka Kawabata, Yoshikazu Hattori, Tomohide Saio, Naito Ishimoto, Tetsuo Asakura, Akira Naito, Hirotsugu Hiramatsu, Saori Akimoto, Young-Ho Lee, Masaki Okumura, Jae-Hyun Park, Sam-Yong Park*, Itsuki Ajioka*, Takahiro Muraoka* (*co-corresponding author)
"Atomic-level design of supramolecular peptide hydrogel disassembler for three-dimensional culture"
ChemRxiv. 28 April 2026. DOI: https://doi.org/10.26434/chemrxiv.15002519/v1
2025
Noriyuki Uchida*, Ryu Ishizaka, Anju Kawakita, Hiroshi Ueno, Hiroyuki Noji, Rinshi S. Kasai, Takeshi Yokoyama, Saburo Kurihara, Tomoki Noguchi, Go Watanabe, Ayaka Iwasaki, Itsuki Ajioka, Kazuyoshi Muranishi, Ken Yoshizawa, Shingo Kanemura, Masaki Okumura, Takahiro Muraoka*
"A Structurally Robust Phospholipid Microtube Constructed by Membrane Phase Separation as a Scaffold for On-Tube Characterization of Membrane-Bound Proteins"
J Am Chem Soc 147, 41706-41716 (2025)
Atsuya Yaguchi, Noriyuki Uchida*, Daiki Miura, Go Watanabe, Hirotsugu Hiramatsu, Itsuki Ajioka, Teruhiko Matsubara, Toshinori Sato, Chin bat Enkhzaya, Shunto Itani, Tomokazu Saito, Takahiro Muraoka*"A Photoresponsive Hybrid of Viruses and Supramolecular Peptide Fibers for Multidimensional Control of Patterning and Infection",
Angew Chem Int Ed 64, e202508528 (2025)
2024
Masanori Uji#, Jumpei Kondo#, Chikako Hara-Miyauchi#, Saori Akimoto, Rena Haruki, Yoichi Sasaki, Nobuo Kimizuka*, Itsuki Ajioka*, Nobuhiro Yanai* (*co-corresponding author)
"In Vivo Optogenetics Based on Heavy Metal-Free Photon Upconversion Nanoparticles"
Adv Mater e2405509 (2024) doi: 10.1002/adma.202405509.
Ryudai Yokokawa*, Chikako Hara-Miyauchi, Itsuki Ajioka, Shingo Maeda
"Mouse Pose Estimation Using Synthetic Dataset Replicating Experimental Environments"
Proc. IEEE ICMA (2024), DOI: 10.1109/ICMA61710.2024.10633032
2023
Noriyuki Uchida*, Yunosuke Ryu, Yuichiro Takagi, Ken Yoshizawa, Kotono Suzuki, Yasutaka Anraku, Itsuki Ajioka, Naofumi Shimokawa, Masahiro Takagi, Norihisa Hoshino, Tomoyuki Akutagawa, Teruhiko Matsubara, Toshinori Sato, Yuji Higuchi, Hiroaki Ito, Masamune Morita, Takahiro Muraoka*
"Endocytosis-Like Vesicle Fission Mediated by a Membrane-Expanding Molecular Machine Enables Virus Encapsulation for In Vivo Delivery"
J Am Chem Soc 145, 6210–6220 (2023)
Yuya Ohno, Chikako Nakajima, Itsuki Ajioka, Takahiro Muraoka, Atsuya Yaguchi, Teppei Fujioka, Saori Akimoto, Misaki Matsuo, Ahmed Lotfy, Sayuri Nakamura, Vicente Herranz-Pérez, José Manuel García-Verdugo, Noriyuki Matsukawa, Naoko Kaneko*, Kazunobu Sawamoto*
"Amphiphilic peptide-tagged N-cadherin forms radial glial-like fibers that enhance neuronal migration in injured brain and promote sensorimotor recovery"
Biomaterials 294, 122003 (2023)
2022
Takahiro Muraoka*, Itsuki Ajioka* (*co-corresponding author)
"Self-assembling Molecular Medicine for the Subacute Phase of Ischemic Stroke"
Neurochem Res 47, 2488-2498 (2022) (review)
2021
Atsuya Yaguchi#, Mio Oshikawa#, Go Watanabe, Hirotsugu Hiramatsu, Noriyuki Uchida, Chikako Hara, Naoko Kaneko, Kazunobu Sawamoto, Takahiro Muraoka*, Itsuki Ajioka* (*co-corresponding author)
"Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration"
Nature Commun 12, 6623 (2021)
Jindan Sheng, Susumu Kohno*, Nobuhiro Okada, Nobuyuki Okahashi, Kana Teranishi, Fumio Matsuda, Hiroshi Shimizu, Paing Linn, Naoko Nagatani, Minako Yamamura, Kenichi Harada, Shin-ichi Horike, Hiroshi Inoue, Seiji Yano, Sharad Kumar, Shunsuke Kitajima, Itsuki Ajioka, Chiaki Takahashi*
"Treatment of Retinoblastoma 1–Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy"
Hepatology 74, 1971-1993 (2021)
Atsuya Yaguchi, Hirotsugu Hiramatsu, Atsuya Ishida, Mio Oshikawa, Itsuki Ajioka, Takahiro Muraoka*
"Hydrogel-stiffening and Non-cell Adhesive Properties of Amphiphilic Peptides with Central Alkylene Chains"
Chem Eur J 27, 9295-9301 (2021)
2020
Atsuya Ishida, Mio Oshikawa, Itsuki Ajioka, and Takahiro Muraoka*
"Sequence-dependent Bioactivity and Self-assembling Properties of RGD-containing Amphiphilic Peptides as Extracellular Scaffolds"
ACS Appl Bio Mater 3, 3605–3611 (2020)
2019
Mariko Komabayashi-Suzuki, Emiko Yamanishi, Chisato Watanabe, Megumi Okamura, Hidenori Tabata, Ryota Iwai, Itsuki Ajioka, Jun Matsushita, Hiroyasu Kidoya, Nobuyuki Takakura, Tadashi Okamoto, Kazuo Kinoshita, Masamitsu Ichihashi, Koh-ichi Nagata, Masatsugu Ema, and Ken-ichi Mizutani*
"Spatiotemporally Dependent Vascularization Is Differently Utilized among Neural Progenitor Subtypes during Neocortical Development"
Cell Rep 29, 1113-1129 (2019)
Yoichi Sasaki, Mio Oshikawa, Pankaj Bharmoria, Hironori Kouno, Akiko Hayashi-Takagi, Moritoshi Sato, Itsuki Ajioka#, and Nobuhiro Yanai#, and Nobuo Kimizuka# (#co-corresponding author)
"Near-infrared optogenetic genome engineering based on photon upconversion hydrogels"
Angew Chem Int Ed 58, 17827-17833 (2019)
Atsuya Ishida, Go Watanabe, Mio Oshikawa, Itsuki Ajioka, and Takahiro Muraoka*
"Glycine Substitution Effects on the Supramolecular Morphology and Rigidity of Cell-Adhesive Amphiphilic Peptides"
Chem Eur J 25, 13523-13530 (2019)
味岡逸樹
"神経組織再生医療（4・6節）"
歯科再生医学（村上 信也, 網塚 憲生, 齋藤 正寛, 松本 卓也 編） , 283-293, (2019), 医歯薬出版株式会社
2019
Mariko Komabayashi-Suzuki, Emiko Yamanishi, Chisato Watanabe, Megumi Okamura, Hidenori Tabata, Ryota Iwai, Itsuki Ajioka, Jun Matsushita, Hiroyasu Kidoya, Nobuyuki Takakura, Tadashi Okamoto, Kazuo Kinoshita, Masamitsu Ichihashi, Koh-ichi Nagata, Masatsugu Ema, and Ken-ichi Mizutani*
"Spatiotemporally Dependent Vascularization Is Differently Utilized among Neural Progenitor Subtypes during Neocortical Development"
Cell Rep 29, 1113-1129 (2019)
Yoichi Sasaki, Mio Oshikawa, Pankaj Bharmoria, Hironori Kouno, Akiko Hayashi-Takagi, Moritoshi Sato, Itsuki Ajioka#, and Nobuhiro Yanai#, and Nobuo Kimizuka# (#co-corresponding author)
"Near-infrared optogenetic genome engineering based on photon upconversion hydrogels"
Angew Chem Int Ed 58, 17827-17833 (2019)
Atsuya Ishida, Go Watanabe, Mio Oshikawa, Itsuki Ajioka, and Takahiro Muraoka*
"Glycine Substitution Effects on the Supramolecular Morphology and Rigidity of Cell-Adhesive Amphiphilic Peptides"
Chem Eur J 25, 13523-13530 (2019)
味岡逸樹
"神経組織再生医療（4・6節）"
歯科再生医学（村上 信也, 網塚 憲生, 齋藤 正寛, 松本 卓也 編） , 283-293, (2019), 医歯薬出版株式会社
2019
Mariko Komabayashi-Suzuki, Emiko Yamanishi, Chisato Watanabe, Megumi Okamura, Hidenori Tabata, Ryota Iwai, Itsuki Ajioka, Jun Matsushita, Hiroyasu Kidoya, Nobuyuki Takakura, Tadashi Okamoto, Kazuo Kinoshita, Masamitsu Ichihashi, Koh-ichi Nagata, Masatsugu Ema, and Ken-ichi Mizutani*
"Spatiotemporally Dependent Vascularization Is Differently Utilized among Neural Progenitor Subtypes during Neocortical Development"
Cell Rep 29, 1113-1129 (2019)
Yoichi Sasaki, Mio Oshikawa, Pankaj Bharmoria, Hironori Kouno, Akiko Hayashi-Takagi, Moritoshi Sato, Itsuki Ajioka#, and Nobuhiro Yanai#, and Nobuo Kimizuka# (#co-corresponding author)
"Near-infrared optogenetic genome engineering based on photon upconversion hydrogels"
Angew Chem Int Ed 58, 17827-17833 (2019)
Atsuya Ishida, Go Watanabe, Mio Oshikawa, Itsuki Ajioka, and Takahiro Muraoka*
"Glycine Substitution Effects on the Supramolecular Morphology and Rigidity of Cell-Adhesive Amphiphilic Peptides"
Chem Eur J 25, 13523-13530 (2019)
味岡逸樹
"神経組織再生医療（4・6節）"
歯科再生医学（村上 信也, 網塚 憲生, 齋藤 正寛, 松本 卓也 編） , 283-293, (2019), 医歯薬出版株式会社
2018
Itsuki Ajioka
"Molecular Technology for Injured Brain Regeneration"
Molecular Technology, Volume 2: Life Innovation (Hisashi Yamamoto & Takashi Kato, Ed). 71-80, (2018), Wiley-VCH, Weinheim.
Hideo Jinnou, Masato Sawada, Koya Kawase, Naoko Kaneko, Vicente Herranz-Pérez, Takuya Miyamoto, Takumi Kawaue, Takaki Miyata, Yasuhiko Tabata, Toshihiro Akaike, José Manuel García-Verdugo, Itsuki Ajioka, Shinji Saitoh, Kazunobu Sawamoto*
"Radial glial fibers promote neuronal migration and functional recovery after neonatal brain injury"
Cell Stem Cell 22, 128-137 (2018)
味岡逸樹
"損傷大脳皮質の再生治療を目指したバイオマテリアル"
バイオマテリアルー生体材料ー 36, 190-195 (2018)
酒井崇匡、味岡逸樹、鄭 雄一
"再生医療や立体組織培養のための高分子足場材料"
再生医療 17, 279-292 (2018)
2018
Itsuki Ajioka
"Molecular Technology for Injured Brain Regeneration"
Molecular Technology, Volume 2: Life Innovation (Hisashi Yamamoto & Takashi Kato, Ed). 71-80, (2018), Wiley-VCH, Weinheim.
Hideo Jinnou, Masato Sawada, Koya Kawase, Naoko Kaneko, Vicente Herranz-Pérez, Takuya Miyamoto, Takumi Kawaue, Takaki Miyata, Yasuhiko Tabata, Toshihiro Akaike, José Manuel García-Verdugo, Itsuki Ajioka, Shinji Saitoh, Kazunobu Sawamoto*
"Radial glial fibers promote neuronal migration and functional recovery after neonatal brain injury"
Cell Stem Cell 22, 128-137 (2018)
味岡逸樹
"損傷大脳皮質の再生治療を目指したバイオマテリアル"
バイオマテリアルー生体材料ー 36, 190-195 (2018)
酒井崇匡、味岡逸樹、鄭 雄一
"再生医療や立体組織培養のための高分子足場材料"
再生医療 17, 279-292 (2018)
2018
Itsuki Ajioka
"Molecular Technology for Injured Brain Regeneration"
Molecular Technology, Volume 2: Life Innovation (Hisashi Yamamoto & Takashi Kato, Ed). 71-80, (2018), Wiley-VCH, Weinheim.
Hideo Jinnou, Masato Sawada, Koya Kawase, Naoko Kaneko, Vicente Herranz-Pérez, Takuya Miyamoto, Takumi Kawaue, Takaki Miyata, Yasuhiko Tabata, Toshihiro Akaike, José Manuel García-Verdugo, Itsuki Ajioka, Shinji Saitoh, Kazunobu Sawamoto*
"Radial glial fibers promote neuronal migration and functional recovery after neonatal brain injury"
Cell Stem Cell 22, 128-137 (2018)
味岡逸樹
"損傷大脳皮質の再生治療を目指したバイオマテリアル"
バイオマテリアルー生体材料ー 36, 190-195 (2018)
酒井崇匡、味岡逸樹、鄭 雄一
"再生医療や立体組織培養のための高分子足場材料"
再生医療 17, 279-292 (2018)
2018
Itsuki Ajioka
"Molecular Technology for Injured Brain Regeneration"
Molecular Technology, Volume 2: Life Innovation (Hisashi Yamamoto & Takashi Kato, Ed). 71-80, (2018), Wiley-VCH, Weinheim.
Hideo Jinnou, Masato Sawada, Koya Kawase, Naoko Kaneko, Vicente Herranz-Pérez, Takuya Miyamoto, Takumi Kawaue, Takaki Miyata, Yasuhiko Tabata, Toshihiro Akaike, José Manuel García-Verdugo, Itsuki Ajioka, Shinji Saitoh, Kazunobu Sawamoto*
"Radial glial fibers promote neuronal migration and functional recovery after neonatal brain injury"
Cell Stem Cell 22, 128-137 (2018)
味岡逸樹
"損傷大脳皮質の再生治療を目指したバイオマテリアル"
バイオマテリアルー生体材料ー 36, 190-195 (2018)
酒井崇匡、味岡逸樹、鄭 雄一
"再生医療や立体組織培養のための高分子足場材料"
再生医療 17, 279-292 (2018)
2018
Itsuki Ajioka*
"Molecular Technology for Injured Brain Regeneration"
Molecular Technology, Volume 2: Life Innovation (Hisashi Yamamoto & Takashi Kato, Ed). 71-80, (2018), Wiley-VCH, Weinheim.
Hideo Jinnou, Masato Sawada, Koya Kawase, Naoko Kaneko, Vicente Herranz-Pérez, Takuya Miyamoto, Takumi Kawaue, Takaki Miyata, Yasuhiko Tabata, Toshihiro Akaike, José Manuel García-Verdugo, Itsuki Ajioka, Shinji Saitoh, Kazunobu Sawamoto*
"Radial glial fibers promote neuronal migration and functional recovery after neonatal brain injury"
Cell Stem Cell 22, 128-137 (2018)
味岡逸樹
"損傷大脳皮質の再生治療を目指したバイオマテリアル"
バイオマテリアルー生体材料ー 36, 190-195 (2018)
酒井崇匡、味岡逸樹、鄭 雄一
"再生医療や立体組織培養のための高分子足場材料"
再生医療 17, 279-292 (2018)
2017
Mio Oshikawa, Kei Okada, Hidenori Tabata, Koh-ichi Nagata, and Itsuki Ajioka# (# corresponding author)
“Dnmt1-dependent Chk1 pathway suppression is protective against neuron division”
Development 144, 3303-3314 (2017)
Mio Oshikawa, Kei Okada, Naoko Kaneko, Kazunobu Sawamoto, and Itsuki Ajioka# (# corresponding author)
“Affinity-Immobilization of VEGF on Laminin Porous Sponge Enhances Angiogenesis in the Ischemic Brain”
Adv Healthc Mater 1700183 (2017)
Teppei Fujioka, Naoko Kaneko, Itsuki Ajioka, Kanako Nakaguchi, Taichi Omata, Honoka Ohba, Reinhard Fässler, José Manuel García-Verdugo, Kiyotoshi Sekiguchi, Noriyuki Matsukawa, Kazunobu Sawamoto*.
“β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain”
EBioMedicine 16, 195-203 (2017)
味岡逸樹
"大脳皮質の再生ー分子技術と神経発生生物学の融合によるアプローチ"
生体の科学 68, 38-42 (2017)
味岡逸樹
"中枢神経系の発生・再生研究においてバイオマテリアルの果たす役割"
バイオマテリアルー生体材料ー 35, 32-35 (2017)
2016
Itsuki Ajioka# (# corresponding author)
“Biomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortex"
Regenerative Therapy 3, 63-67 (2016) (review)
Nobutaka Ishizu, Daishi Yui, Akira Hebisawa, Hidenori Aizawa, Wanpeng Cui, Yuko Fujita, Kenji Hashimoto, Itsuki Ajioka, Hidehiro Mizusawa, Takanori Yokota, and Kei Watase.
“Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice”
Hum Mol Genet 25, 4507-4517 (2016)
2015
Issam Aldiri*, Itsuki Ajioka*, Beisi Xu, Jiakun Zhang, Xiang Chen, Claudia Benavente, David Finkelstein, Dianna Johnson, Jennifer Akiyama, Len A. Pennacchio, and Michael A. Dyer (*co-first author)
“Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma”
Development 142, 4092-4106 (2015)
Itsuki Ajioka#*, Hideo Jinnou*, Kei Okada, Masato Sawada, Shinji Saitoh, and Kazunobu Sawamoto# (# co-corresponding author, *co-first author)
"Enhancement of neuroblast migrationinto the injured cerebral cortex using laminin-containing porous sponge"
Tissue Eng Part A 21, 193-201 (2015)
Daishi Yui, Yoichiro Nishida, Tomoko Nishina, Kaoru Mogushi, Mio Tajiri, Satoru Ishibashi, Itsuki Ajioka, Kinya Ishikawa, Hidehiro Mizusawa, Shigeo Murayama, and Takanori Yokota.
“Enhanced phospholipase A2 group 3 expression by oxidative stress decreases the insulin-degrading enzyme”
PLoS ONE 10, e0143518 (2015)
2014
Itsuki Ajioka# (# corresponding author)
“Coordination of proliferation and differentiation by the retinoblastoma protein family"
Dev Growth Differ 56, 324-334 (2014) (review)
Hirofumi Fujita, Hanako Aoki, Itsuki Ajioka, Maya Yamazaki, Manabu Abe, Arata Oh-Nishi, Kenji Sakimura, Izumi Sugihara.
“Detailed expression pattern of Aldolase C (Aldoc) in the cerebellum, retina and other areas of the CNS studied in Aldoc-Venus knock-in mice”
PLoS ONE 9, e86679, (2014)
味岡逸樹
“神経前駆細胞において増殖と分化の協調を制御するRbファミリータンパク質の役割”
生化学 86, 489-492 (2014)
2013
Mio Oshikawa, Kei Okada, Kazunori Nakajima, and Itsuki Ajioka# (# corresponding author)
“Cortical excitatory neurons become protected from cell division during neurogenesis in an Rb family-dependent manner”
Development 140, 2310-2320 (2013)
2011
Itsuki Ajioka#, Shizuko Ichinose, Kazunori Nakajima, and Hidehiro Mizusawa (# corresponding author)
“Basement membrane-like matrix sponge for the three-dimensional proliferation culture of differentiated retinal horizontal interneurons”
Biomaterials 32, 5765-5772 (2011)