ACHIEVEMENT
Selected Publication
Uji M#, Kondo J#, Hara-Miyauchi C#, Akimoto S, Haruki R, Sasaki Y, Kimizuka N*, Ajioka I*, Yanai N* (*co-corresponding author)
In Vivo Optogenetics Based on Heavy Metal-Free Photon Upconversion Nanoparticles.
Adv Mater e2405509, 2024. doi: 10.1002/adma.202405509.
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Yaguchi A#, Oshikawa M#, Watanabe G, Hiramatsu H, Uchida N, Hara C, Kaneko N, Sawamoto K, Muraoka T*, Ajioka I* (*co-corresponding author)
Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration
Nature Commun 12:6623, 2021
Technology Introduction (English)
Video Abstract (English)​​
Press Release (Japanese)​​
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Sasaki Y, Oshikawa M, Bharmoria P, Kouno H, Hayashi-Takagi A, Sato M, Ajioka I*, Yanai N*, Kimizuka N* (*co-corresponding author)
Near-infrared optogenetic genome engineering based on photon upconversion hydrogels
Angew Chem Int Ed 58:17827-17833, 2019
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Oshikawa M, Okada K, Kaneko N, Sawamoto K, and Ajioka I* (*corresponding author)
Affinity-Immobilization of VEGF on laminin porous sponge enhances angiogenesis in the ischemic brain
Adv Healthc Mater 1700183, 2017.
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Oshikawa M, Okada K, Tabata H, Nagata KI, and Ajioka I* (*corresponding author)
Dnmt1-dependent Chk1 pathway suppression is protective against neuron division
Development 144, 3303-3314, 2017
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Aldiri I#, Ajioka I#, Xu B, Zhang J, Chen X, Benavente C, Finkelstein D, Johnson D, Akiyama J, Pennacchio LA, and Dyer MA (#co-first author)
Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma
Development 142, 4092-4106, 2015.
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​Oshikawa M, Okada K, Nakajima K, Ajioka I* (*corresponding author)
Cortical excitatory neurons become protected from cell division during neurogenesis in an Rb family-dependent manner
Development 140:2310-2320, 2013.
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Ajioka I*, Ichinose S, Nakajima K, Mizusawa H. (*corresponding author)
Basement membrane-like matrix sponge for the three-dimensional proliferation culture of differentiated retinal horizontal interneurons.
Biomaterials 32:5765-5772, 2011.
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Ajioka I, Martins R, Bayazitov IT, Donovan S, Johnson D, Frase S, Cicero S, Boyd K, Zakharenko SS, Dyer MA.
Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice
Cell 131:378-390, 2007.​​
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Full Publication (click here)
2025
Noriyuki Uchida*, Ryu Ishizaka, Anju Kawakita, Hiroshi Ueno, Hiroyuki Noji, Rinshi S. Kasai, Takeshi Yokoyama, Saburo Kurihara, Tomoki Noguchi, Go Watanabe, Ayaka Iwasaki, Itsuki Ajioka, Kazuyoshi Muranishi, Ken Yoshizawa, Shingo Kanemura, Masaki Okumura, Takahiro Muraoka*
"A Structurally Robust Phospholipid Microtube Constructed by Membrane Phase Separation as a Scaffold for On-Tube Characterization of Membrane-Bound Proteins"
J Am Chem Soc 147, 41706-41716 (2025)
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Atsuya Yaguchi, Noriyuki Uchida*, Daiki Miura, Go Watanabe, Hirotsugu Hiramatsu, Itsuki Ajioka, Teruhiko Matsubara, Toshinori Sato, Chin bat Enkhzaya, Shunto Itani, Tomokazu Saito, Takahiro Muraoka*"A Photoresponsive Hybrid of Viruses and Supramolecular Peptide Fibers for Multidimensional Control of Patterning and Infection",
Angew Chem Int Ed 64, e202508528 (2025)​​
2024
Masanori Uji#, Jumpei Kondo#, Chikako Hara-Miyauchi#, Saori Akimoto, Rena Haruki, Yoichi Sasaki, Nobuo Kimizuka*, Itsuki Ajioka*, Nobuhiro Yanai* (*co-corresponding author)
​​"In Vivo Optogenetics Based on Heavy Metal-Free Photon Upconversion Nanoparticles"
Adv Mater e2405509 (2024) doi: 10.1002/adma.202405509.
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Ryudai Yokokawa*, Chikako Hara-Miyauchi, Itsuki Ajioka, Shingo Maeda
"Mouse Pose Estimation Using Synthetic Dataset Replicating Experimental Environments"
Proc. IEEE ICMA (2024), DOI: 10.1109/ICMA61710.2024.10633032​​​​
2023
Noriyuki Uchida*, Yunosuke Ryu, Yuichiro Takagi, Ken Yoshizawa, Kotono Suzuki, Yasutaka Anraku, Itsuki Ajioka, Naofumi Shimokawa, Masahiro Takagi, Norihisa Hoshino, Tomoyuki Akutagawa, Teruhiko Matsubara, Toshinori Sato, Yuji Higuchi, Hiroaki Ito, Masamune Morita, Takahiro Muraoka*
"Endocytosis-Like Vesicle Fission Mediated by a Membrane-Expanding Molecular Machine Enables Virus Encapsulation for In Vivo Delivery"
J Am Chem Soc 145, 6210–6220 (2023)
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Yuya Ohno, Chikako Nakajima, Itsuki Ajioka, Takahiro Muraoka, Atsuya Yaguchi, Teppei Fujioka, Saori Akimoto, Misaki Matsuo, Ahmed Lotfy, Sayuri Nakamura, Vicente Herranz-Pérez, José Manuel García-Verdugo, Noriyuki Matsukawa, Naoko Kaneko*, Kazunobu Sawamoto*
"Amphiphilic peptide-tagged N-cadherin forms radial glial-like fibers that enhance neuronal migration in injured brain and promote sensorimotor recovery"
Biomaterials 294, 122003 (2023)
2022
Takahiro Muraoka*, Itsuki Ajioka* (*co-corresponding author)
"Self-assembling Molecular Medicine for the Subacute Phase of Ischemic Stroke"
Neurochem Res 47, 2488-2498 (2022) (review)
2021
Atsuya Yaguchi#, Mio Oshikawa#, Go Watanabe, Hirotsugu Hiramatsu, Noriyuki Uchida, Chikako Hara, Naoko Kaneko, Kazunobu Sawamoto, Takahiro Muraoka*, Itsuki Ajioka* (*co-corresponding author)
"Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration"
Nature Commun 12, 6623 (2021)
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Jindan Sheng, Susumu Kohno*, Nobuhiro Okada, Nobuyuki Okahashi, Kana Teranishi, Fumio Matsuda, Hiroshi Shimizu, Paing Linn, Naoko Nagatani, Minako Yamamura, Kenichi Harada, Shin-ichi Horike, Hiroshi Inoue, Seiji Yano, Sharad Kumar, Shunsuke Kitajima, Itsuki Ajioka, Chiaki Takahashi*
"Treatment of Retinoblastoma 1–Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy"
Hepatology 74, 1971-1993 (2021)
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Atsuya Yaguchi, Hirotsugu Hiramatsu, Atsuya Ishida, Mio Oshikawa, Itsuki Ajioka, Takahiro Muraoka*
"Hydrogel-stiffening and Non-cell Adhesive Properties of Amphiphilic Peptides with Central Alkylene Chains"
Chem Eur J 27, 9295-9301 (2021)